Friday, March 12, 2010

Find a protein using PDB explorer-decribe your protein, including what disease state or other real-world application it has.


The YIxR protein was part of the streptococcus pneumonia and its purpose was not yet known. It derived from a small group of protein called alpha-beta plait super family that had motif GRGA. Their protein was not the same as other protein; moreover, their structure was similar to a double layer alpha/beta sandwich. The protein structure was identified through semi-automated. It had a positive charge side with three sulfate ion attached, which located in the nucleic acid binding proteins. The protein later was verified as the RNA-binding protein.

Streptococcus pneumonia was commonly discovered in the nasopharynx. It was a bacterium often known as “carriage.” Younger children were prone to the infection. If this organism reached other body parts, it would most likely cause ear infection, sinus infection, and lung infection. If it traveled into the bloodstream it could cause meningitis. This type of disease was known to be invasive, which could lead to dead. This organism was most often found in bacterial meningitis, bacteremia, otitis media and community-acquired pneumonia.


source:
http://www.ncbi.nlm.nih.gov/Structure/mmdb/mmdbsrv.cgi?uid=17085




http://www.cdc.gov/ncidod/aip/research/spn.html

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